Antonio Gil-nagel Rein

Dr. Antonio Gil-nagel Rein performs genetic diagnosis and treatment for complex epilepsy. He is a founding member of the European Epilepsy Research Network. At Hospital Ruber Internacional, he leads a program that uses interstitial laser treatments and interstitial radiotherapy.

Advanced Epilepsy Specialization

Dr. Gil-nagel Rein treats refractory epilepsy in children and adults. He specializes in orphan conditions like Dravet syndrome and Lennox-Gastaut syndrome. His unit uses deep electrodes and drug repositioning to treat patients who do not respond to standard care.

The doctor performs precise procedures to treat seizures. These include Gamma Knife radiosurgery — a non-invasive form of radiation therapy — and vagus nerve stimulation. He also implements ketogenic diets and electrical stimulation for seizure control.

Professional Achievements

Dr. Gil-nagel Rein directs the Epilepsy Department at Francisco Vitoria University. He is also a professor at IE University and an Ad Honorem Professor at the Polytechnic University of Madrid. He has trained over 150 specialists from Europe and Latin America. Additionally, his team received the 2021 Innovative Small and Medium Enterprise Award for work on temporal lobe epilepsy.

• 2012 – Scientific Award from the Spanish Society of Neurology Epilepsy Group.
• Principal Investigator for phase II and III pharmacological clinical trials.
• Author of 165 Scopus-indexed articles with over 5,000 citations.
• Published research in the New England Journal of Medicine and Nature Neurology.

Academic and Work History

• 1985 – Bachelor of Medicine and Surgery, Complutense University of Madrid.
• 1986–1989 – Residency in Neurology, Hospital 12 de Octubre, Madrid.
• 1991–1993 – Epilepsy Fellowship, University of Minnesota, USA.
• 1993–1995 – Associate Professor, University of Minnesota, USA.
• 1995–1998 – Associate Professor, Rush-Presbyterian-St. Luke's Medical Center, Chicago.
• Since 1998 – Director of the Epilepsy Unit, Hospital Ruber Internacional.
• 2014 – Defended dissertation on clinical and neurophysiological studies in pre-surgical epilepsy evaluation at Complutense University of Madrid.
• 2022 – Deputy Head of Neurology, Hospital Ruber Internacional.

International Leadership & Memberships

Dr. Gil-nagel Rein represents Spain in the World Federation of Neurology (WFN) and serves on its editorial committee. He helps shape clinical standards through the European Federation of Neurological Societies. The specialist also contributes to the EpiCare and European Epilepsy Brain Bank research projects.

• Founder of the European Association for Epilepsy Monitoring.
• American Board of Clinical Neurophysiology certified (1997).
• Member of the American Academy of Neurology since 1991.
• Member of the American Epilepsy Society since 1991.
• Member of the American Society of Clinical Neurophysiology since 1996.
• Member of the Spanish Society of Neurology since 1988.
• Former Director of the Epilepsy Group for the European Federation of Neurological Societies.
• Member of the Scientific Committee for the 2009 World Congress of Neurologists.