Halaman 2 - MRI seluruh tubuh Dokter Terbaik - TOP-26 dokter

Dr. Oren Shibolet is a highly experienced gastroenterologist and hematologist with over 50 years of practice. He is a leading expert in liver conditions and treatments, having served as the Head of the Liver Unit at Sourasky (Ichilov) Medical Center. He has a degree in general medicine from the Hebrew University, a specialty in gastroenterology from the Hebrew University Hadassah Medical School, and is a member of multiple medical organizations. He is also an author of over 60 publications and 100 conference reports.

Areas of Interests

• Breast cancer
• Lung cancer
• Colorectal cancers
• Gynecological and urogenital cancers
• Molecular Oncology

Education:

• Kızıltepe Anatolian High School 2001
• Dicle University Faculty of Medicine 2007
• Istanbul Medeniyet University Göztepe Training and Research Hospital 2014
• Kartal City Hospital 2021
• Associate Professor of Medical Oncology 2023

Experience:

• Liv Hospital Ulus
• Adıyaman University Training and Research Hospital
• Istanbul Umraniye Training and Research Hospital
• Istanbul Umraniye Training and Research Hospital

Research:

• Phase II, Randomized, Open-Label, Multicenter Study to Comparatively Evaluate the Efficacy and Safety of GDC-9545 and Physician-Preferred Endocrine Monotherapy in Previously Treated, Estrogen Receptor Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer Patients, Other ( International), Dr. Murat Ayhan
• Phase III, Randomized, Evaluating the Efficacy and Safety of Palbociclib and Fulvestrant with Gdc-0077 Compared with Placebo in Patients with Pik3ca-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer. Double Blind, Placebo Controlled Study, Other (International), Dr. Murat Ayhan
• Randomized, Multicenter, Phase Ib/III Study Evaluating the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Atezolizumab Compared to Intravenous Atezolizumab in Patients with Previously Treated Locally Advanced or Metastatic Non-Small Cell Lung Cancer, Other (International) Dr. Murat Ayhan
• Randomized, Controlled, Multicenter, Open-Label Study Including Observation Follow-Up for PSMA-PET-Negative Patients, Investigating the Efficacy and Safety of Addition of Apalutamide to Radiotherapy and LHRH Agonist in PSMA-PET-Positive High-Risk Hormone-Sensitive Prostate Cancer Patients, Other (International) Dr. Murat Ayhan
• Biomarker Study to Identify Patients with Advanced Stage Urothelial Cancer and Fibroblast Growth Factor Receptor Gene Aberrations-42756493BLC0002, Other (International), Dr. Murat Ayhan
• Publications:
• Ayhan M, Turan N, Köstek O, et all. Does the efficacy of regorafenib differ in chemotherapy refractory metastatic colorectal cancer patients who had mucinous pathology compared to those who had non-mucinous pathology? Curr Probl Cancer. 2021 Jun;45(3):100670. doi: 10.1016/j.currproblcancer.2020.100670.
• Ayhan M, Odabas H, Turan N, et all. Factors affecting the mortality rate of patients with cancer hospitalized with COVID-19: a single center's experience. J Chemother. 2021 Nov;33(7):499-508. doi: 10.1080/1120009X.2021.1923153.
• Ayhan M, Laçin Ş, Özyükseler DT, et all. Does systemic anti-tumor therapy increase COVID-19 risk in patients with cancer? J Oncol Pharm Pract. 2021 Sep;27(6):1461-1467. doi: 10.1177/10781552211015762.
• Ayhan M, Abamor E, Coban Kokten S, et al. Value of FDG PET/CT in Predicting Pathologic Complete Response After Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer. EJMI 2022;6(2):165–175.
• Ayhan M, Terzioglu K. Experience With Rapid Drug Desensitization With Chemotherapeutics; A SingleCentre Retrospective Study. EJMI 2021;5(3):380–387.
• Doğan A, AYHAN M. Survival analysis of patients with triple-negative breast cancer: a single-center experience. Journal of Oncological Sciences, 8(2), 94-99., Doi: 10.37047/jos.2022-89749
• Terzioğlu K, Ayhan M. Comparative Assessment of Platinum Salts and Taxane Group Hypersensitivity Reactions, The Role of Skin Tests in Diagnosis? J Oncol Pharm Pract. 2021 Nov 30:10781552211050084. doi: 10.1177/10781552211050084.
• Tacar SY, Selcukbiricik F, Yilmaz M, Erturk K, Murat Sarici A, Gulturk I, Ayhan M, Tural D. Nivolumab for metastatic uveal melanoma: a multicenter, retrospective study. Melanoma Res. 2021 Oct 1;31(5):449-455. doi: 10.1097/CMR.0000000000000744.
• Özyurt E, Özçelik S, Sürmeli H, Çelik M, Ayhan M, Özçelik M. Side effects of immune-checkpoint inhibitors: Can multiple side effects be seen in a patient? J Oncol Pharm Pract. 2022 Mar;28(2):462-465. doi: 10.1177/10781552211038136.
• Dülgar Ö, Öven BB, Atcı MM, Arıkan R, Ay S, Ayhan M, Selvi O, Ozyukseler DT, Bayram E, Özcan E, Yasin Aİ, Gümüş M. Is the benefit of using adjuvant capecitabine in patients with residual triple-negative breast cancer related to pathological response to neoadjuvant chemotherapy? Expert Rev Anticancer Ther. 2022 Jul;22(7):773-780. doi: 10.1080/14737140.2022.2076670.
• Hizal M, Bilgin B, Paksoy N, Ayhan M, et all. The real-life efficacy and safety of osimertinib in pretreated advanced non-small cell lung cancer patients with T790M mutation: a Turkish Oncology Group Study. J Cancer Res Clin Oncol. 2022 Jun;148(6):1501-1508. doi: 10.1007/s00432-021-03748-7.
• Volume I, Kucukarda A, Atcı MM, Ayhan M, et all. Efficacy and safety of trastuzumab emtansine in older patients with HER2-positive advanced breast cancer: a real-world study. Tumori. 2022 Feb;108(1):19-25. doi: 10.1177/03008916211037739.
• Dogan I, Ayhan M, Gurbuz M, et all. The frequency and prognostic significance of ABO/Rh blood groups in male breast cancer patients: A multicenter study. Medicine (Baltimore). 2022 Sep 2;101(35):e30147. doi: 10.1097/MD.0000000000030147.
• Ozcelik M, Oyman A, Cil I, Duzgun O, Ozkan OF, Ayhan M. Cytoreductive Surgery versus Systemic Chemotherapy alone in Isolated Peritoneal Carcinomatosis of Colorectal Origin. J Coll Physicians Surg Pak. 2021 Nov;31(11):1308-1313. doi: 10.29271/jcpsp.2021.11.1308.
• Başoğlu T, Sakin A, Erol C, Ayhan M, et all. Real life experienceof patients with locally advanced gastric and gastroesophageal junction adenocarcinoma treated with neoadjuvant chemotherapy: a Turkish oncology group study. J Chemother. 2022 May 17:1-8. doi: 10.1080/1120009X.2022.2073159.
• Özdemir Ö, Zengel B, Yildiz Y, Ayhan M, et all. The effectiveness and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early-stage human epidermal growth factor receptor 2-positive breast cancer: Turkish Oncology Group study. Anticancer Drugs. 2022 Aug 1;33(7):663-670. doi: 10.1097/CAD.0000000000001310.
• Hizal M, Bilgin B, Paksoy N, Ayhan M, et all. The percentage of ALK-positive cells and the efficacy of first-line alectinib in advanced non-small cell lung cancer: is it a novel factor for stratification? (Turkish Oncology Group Study). J Cancer Res Clin Oncol. 2022 Sep 1. doi: 10.1007/s00432-022-04252-2.
• Hizal M, Bilgin B, Paksoy N, Ayhan M, et all. Real-world data on efficacy and safety of first-line alectinib treatment in advanced-stage, ALK-positive non-small-cell lung cancer patients: a Turkish Oncology Group study. Future Oncol. 2022 Jul;18(23):2573-2582. doi: 10.2217/fon-2022-0083.
• Topcu A, Atci MM, Secmeler S, Besiroglu M, Ayhan M, Ozkan M, Bozkurt O, Urakci Z, Ay S, Geredeli C, Yasin AI, Turk HM. Efficacy of trastuzumab and potential risk factors on survival in patients with HER2-positive metastatic gastric cancer. Future Oncol. 2021 Nov;17(31):4157-4169. doi: 10.2217/fon-2021-0398.
• Bilgin B, Sendur MAN, Yucel S, Ayhan M, et all. Real-life comparison of the afatinib and first-generation tyrosine kinase inhibitors in nonsmall cell lung cancer harboring EGFR exon 19 deletion: a Turk Oncology Group (TOG) study. J Cancer Res Clin Oncol. 2021 Jul;147(7):2145-2152. doi: 10.1007/s00432-020-03501-6.
• Atci MM, Akagunduz B, Demir M, Arikan R, Ay S, Ozer M, Ayhan M, Cil I, Demir N, Ozyurt N, Karakaya G, Cevik GT, Onder AH, Selvi O, Sakin A. The impact of adjuvant oxaliplatin and tumor sidedness on the overall survival of stage IIB colon cancer patients: a multicentre study. J Chemother. 2023 Feb;35(1):19-28. doi: 10.1080/1120009X.2022.2040770.
• Tataroglu Ozyukseler D, Ay S, Turan M, Alkan G, Ayhan M, Surmeli H, et al. The Systemic Inflammation Response Index as a Prognostic Marker in Advanced Pancreatic Cancer. EJMI 2022;6(3):367–373.
• Yıldız F, Ayhan M, Demir H, et all. Comparing the efficacy of cabazitaxel in secondline and third-Line treatment of metastatic castration-resistant prostate cancer: a multi-center experience from Turkey. International Journal of Contemporary Medical Research, 7(9), 112-116.,Doi: 10.21276/ijcmr.2020.7.9.30
• Terzioğlu K, Ayhan M. Distribution of allergens detected on patch tests of patients with allergic contact dermatitis and investigation of their atopic background. Annals of Medical Research, 29(5), 422-426., doi: 10.5455/annalsmedres.2021.07.490
• Arikan R, Atci MM, Ay S, Ayhan M, et all Prognostic significance of mucinous histology in left sided metastatic colorectal cancers with wild type RAS and evaluation of backbone chemotherapy regimens. Oncol Lett. 2023 Apr 5;25(5):208. doi: 10.3892/ol.2023.13795.
• Almuradova E, Yalcin S, Arıkan R, Ayhan M, Demir H, Cevik GT, Karaca M, Petekkaya I, Karabulut B. Survival of Patients With Metastatic Rectum Cancer Who Underwent Metastasectomy Following Conversion Chemotherapy Sans Pelvic Radiotherapy: A Turkish Oncology Group Study. Cureus 2023 May 17;15(5):e39119. doi: 10.7759/cureus.39119.
• Topcu A, Besiroglu M, Atci MM, Ayhan M, et all. Second-line Therapy after Trastuzumab Failure in HER2-Positive Metastatic Gastric Cancer: A Real-life Data. EJMI 2023;7(2):153–161. DOI: 10.14744/ejmi.2023.22720
• Book Writing:
• Drug interactions and side effects of targeted agents, Section name: (Small molecule tyrosine kinase inhibitors; ROS-1 targeted therapies (Crizotinib, Seritinib)) (2021)., AYHAN MURAT, Turkish Clinics Journal of Medical Sciences, Editor: Mehmet Aliustaoglu, Publishing number:1, Number of Pages 92, ISBN:978-625-401- 466-6, Turkish
• Approach to gastrointestinal stromal tumors and neuroendocrine tumors, Department name: (Medical approach in primary non-gastrointestinal neuroendocrine tumors) (2020)., AYHAN MURAT, Akademisyen Yayınevi, Editor: Anılır Ender, Number of editions: 1, Number of Pages 382, ISBN: 9786052585719, Turkish
• Internal medicine emergencies, Department name: (Oncological emergencies) (2022)., YILDIRIM SEDAT, AYHAN MURAT, Efe Academic Publishing, Editor: Serdar Olt, Number of editions: 1, Number of Pages 232, ISBN: 978-625-8324-66- 2, Turkish
• Physicians' chemotherapy cancer drug manual 2020, Section name: (Common chemotherapy regimens in clinical practice) (2022)., SÜMBÜL AHMET TANER, ALKAN ALI, AKSOY ASUDE, AYHAN MURAT, et all, Türkiye Klinikleri Journal of Medical Sciences, Editor: EDWAR CHU, VINCENT T. DEVITA, SAADDETIN KILIÇKAP, CEMIL BILIR, SELÇUK SEBER, Number of editions: 1, Number of pages 772, ISBN: 978-625-401-290- 7, Turkish (Book Translation)

Areas of Interests

• Rheumatoid Arthritis
• Psoriatic arthritis
• Ankylosing Spondylitis and other Spondyloarthropathies
• Systemic Lupus Erythematosus
• Sjögren Syndrome
• Scleroderma
• Vasculitis
• Behçet's Disease
• Familial Mediterranean Fever (FMF)
• Inflammatory Myositis
• Fibromyalgia and other Pain Syndromes
• Osteoarthritis
• Gout, pseudogout crystal arthropathies

Education:

• Bingöl Anadolia Teacher High School
• İstanbul Üni. İstanbul Faculty of Medicine,
• İstanbul Üni. İstanbul Faculty of Medicine, Training of İnternal Medicine Specialist
• İstanbul Üni. İstanbul Faculty of Medicine, Training of Rheumatology Specialist
   

Residency:

• Residency, Department of Neurosurgery, Gazi University

Previous Employments:

• Bingöl Adaklı Public Healtcare Center , General Medical Practicer
• Mardin Kızıltepe Goverment Hospital İnternal Medicine Specialtist
• Şanlıurfa Training and Reserching Hospital, Rheumatology Specialtist
• Liv Hospital Vadi İstanbul Rheumatology Specialtist

• Education
• 1992-1999 - Faculty of Medicine, Technion.
• Specialization
• 2000-2005 - Internship, Institute of Visualization, Tel Aviv Sourasky Medical Center (Ichilov).
• Recognized experience
• Diagnostic radiology
• Subspecialization:
• 2005-2007 - Breast imaging, Mammography Institute, Tel Aviv Medical Center.
• Additional education
• 2008 - MRI of the mammary gland, internship at the Medical Center of the Curie Institute, Paris, France.
• 2012 - Training period in advanced breast imaging technologies at the Gustave Roussy Cancer Center, Villejuif, France.
• 2009,2011,2013 - Updated courses on breast visualization.
• Clinical experience
• 2013 - Director of the Mammography Department, Tel Aviv Medical Center.
• 2007 - Maccabi HMO Breast Imaging Consultant.
• 2005 - Senior Physician, Sourasky Medical Center, Tel Aviv.
• 2000-2005 - Internship, Institute of Visualization, Sourasky Medical Center, Tel Aviv.
• 1999-2000 - Internship, Sheba Medical Center.
• Academic experience
• 2010- Breast imaging training for medical students in clinical years, Department of Imaging, Faculty of Medicine, Tel Aviv University
• 2013 - Lecturer for surgical interns, School of Continuing Education, School of Medicine, Tel Aviv University.
• 2000-2005 - Lecturer in Visualization at the School of Radiography, Sourasky Medical Center, Tel Aviv, Bar-Ilan University.
• Trade union membership
• Israel Association of Radiologists
• Breast Imaging Department
• Israel Medical Association
• North American Society of Radiology.
• Areas of special interest and activities
• Breast biopsy and preoperative MRI-guided marking.
• Breast visualization in automated 3D ultrasound.
• Removal of breast lumps using non-invasive radiofrequency technology (BLES).
• Mammography with the introduction of a contrast agent.
• Molecular Breast Imaging, MBI (Molecular Breast Imaging)

Medical Interests and Activities 

• Gastrointestinal diseases 

• Oncologic laparoscopic surgery 

• Anorectal area diseases 

• Urgent surgical cases (acute cholecystitis, divertikülit, ileus, pankreatit, appendicitis) 

• Colon and rectum cancer 

• Treatment of oncologic surgical cases with further laparoscopic and robotic surgery. • Laparoskopik hernia surgery 

• Esophagus and stomach cancer 

• Selim anorectal diseases (hemorrhoidal disease, anal fissure), perianal fistula, pilonoidal sinus (hairless- non-surgical treatment)

Education and Experience 

• İstanbul University Medical Faculty 1988 • University of Colorado Health Science Center – Intern Surgeon 

• Isparta, Dedeçam Şehit Ramazan Karaca Health Center (1995-1996) • İstanbul Surgery Hospital – American Hospital (2000-2001) 

• Chief assistant Istanbul Medical Faculty, Department of General Surgery (2001-2008) • World Congress on Peritonel Surface Malignancies (HIPEC course) Berlin, Germany (2012) 

• USC Keck School of Medicine, Los Angeles, CA, USA (2006-2007) 

• Assoc. Prof. M.D. , İstanbul Medical Faculty General Surgery (2008-2014) 

• Da Vinci Robotic Intensive Course at IRCAD, Strasbourg, France (2011) 

• Stony Brook Medicine Cadaver Training Event in Colon and Rectal Surgery, New York, USA (2016) (Instructor) 

• Fellow of the European Board of Surgery- Emergency Surgery (FEBS EmSurg) Honorary Diploma (2017) 

• Prof. M.D. , İstanbul Medical Faculty General Surgery (2014 -2017) 

• İstanbul University Medical Faculty – General Surgery Master of Science 1996 

• University of Southern California Medical Center, Department of General Surgery, Los Angeles, USA – February 2006 – February 2007

Scientific Publications • Endoscopic Laparoscopic & Minimal Invasive Surgery Journal Editorial Board / National Scientific Committee • UTACD Assist. Editor

Areas of Interests

• MR Linac
• Three Dimensional Brachytherapy
• Four Dimensional (4D) Radiotherapy
• Stereotactic RT & IMRT
• Breast Cancer, Gynecological Cancers
• Head – Neck Cancers
• Urological Tumors, Gastrointestinal Cancers
• Lung Cancer
• Central Nervous System Tumors & Metastases
• Skin Cancers
• Soft Tissue Tumors

Education:

• Istinye University Medical Faculty, Professor Doctor (2017 – Continued)
• Istine University Medical Faculty Associate Professor Doctor (2016 – 2017)
• Liv Hospital Radiation Medicine Center, Tbilisi, Georgia, Radiation Oncology Consulting Docor (2016 – 2019)
• Liv Hospital, Radiation Oncology (2015 – Continued)
• Istanbul University Oncology Institution, Associate Professor (2012 – 2015)
• Stereotactic Radiotherapy, Thoracic Oncology, University of North Carolina, NC, USA (2010 – 2011)
• Kocaeli University Radiation Oncology Department, Associate Professor Assistant (2006 – 2009)
• GATA Radiation Oncology Department, Specialist Doctor, Reserve Officer (2004 – 2005)
• Istanbul University, Medical Faculty, Dr.R.A. (1999 – 2004)
• Istanbul University, Medical Faculty, Under-Graduate (1993 – 1999)
   

Experience:

• Istinye University Medical Faculty
• Liv Hospital Ulus
• Istanbul University Oncology Institution
• University of North Carolina, NC, USA
• Kocaeli University Medical Faculty
• Istanbul University, Medical Faculty