Halaman 2 - Fibroscan Dokter Terbaik di Turquia - TOP-26 dokter

Areas of Interests

• Breast cancer
• Lung cancer
• Colorectal cancers
• Gynecological and urogenital cancers
• Molecular Oncology

Education:

• Kızıltepe Anatolian High School 2001
• Dicle University Faculty of Medicine 2007
• Istanbul Medeniyet University Göztepe Training and Research Hospital 2014
• Kartal City Hospital 2021
• Associate Professor of Medical Oncology 2023

Experience:

• Liv Hospital Ulus
• Adıyaman University Training and Research Hospital
• Istanbul Umraniye Training and Research Hospital
• Istanbul Umraniye Training and Research Hospital

Research:

• Phase II, Randomized, Open-Label, Multicenter Study to Comparatively Evaluate the Efficacy and Safety of GDC-9545 and Physician-Preferred Endocrine Monotherapy in Previously Treated, Estrogen Receptor Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer Patients, Other ( International), Dr. Murat Ayhan
• Phase III, Randomized, Evaluating the Efficacy and Safety of Palbociclib and Fulvestrant with Gdc-0077 Compared with Placebo in Patients with Pik3ca-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer. Double Blind, Placebo Controlled Study, Other (International), Dr. Murat Ayhan
• Randomized, Multicenter, Phase Ib/III Study Evaluating the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Atezolizumab Compared to Intravenous Atezolizumab in Patients with Previously Treated Locally Advanced or Metastatic Non-Small Cell Lung Cancer, Other (International) Dr. Murat Ayhan
• Randomized, Controlled, Multicenter, Open-Label Study Including Observation Follow-Up for PSMA-PET-Negative Patients, Investigating the Efficacy and Safety of Addition of Apalutamide to Radiotherapy and LHRH Agonist in PSMA-PET-Positive High-Risk Hormone-Sensitive Prostate Cancer Patients, Other (International) Dr. Murat Ayhan
• Biomarker Study to Identify Patients with Advanced Stage Urothelial Cancer and Fibroblast Growth Factor Receptor Gene Aberrations-42756493BLC0002, Other (International), Dr. Murat Ayhan
• Publications:
• Ayhan M, Turan N, Köstek O, et all. Does the efficacy of regorafenib differ in chemotherapy refractory metastatic colorectal cancer patients who had mucinous pathology compared to those who had non-mucinous pathology? Curr Probl Cancer. 2021 Jun;45(3):100670. doi: 10.1016/j.currproblcancer.2020.100670.
• Ayhan M, Odabas H, Turan N, et all. Factors affecting the mortality rate of patients with cancer hospitalized with COVID-19: a single center's experience. J Chemother. 2021 Nov;33(7):499-508. doi: 10.1080/1120009X.2021.1923153.
• Ayhan M, Laçin Ş, Özyükseler DT, et all. Does systemic anti-tumor therapy increase COVID-19 risk in patients with cancer? J Oncol Pharm Pract. 2021 Sep;27(6):1461-1467. doi: 10.1177/10781552211015762.
• Ayhan M, Abamor E, Coban Kokten S, et al. Value of FDG PET/CT in Predicting Pathologic Complete Response After Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer. EJMI 2022;6(2):165–175.
• Ayhan M, Terzioglu K. Experience With Rapid Drug Desensitization With Chemotherapeutics; A SingleCentre Retrospective Study. EJMI 2021;5(3):380–387.
• Doğan A, AYHAN M. Survival analysis of patients with triple-negative breast cancer: a single-center experience. Journal of Oncological Sciences, 8(2), 94-99., Doi: 10.37047/jos.2022-89749
• Terzioğlu K, Ayhan M. Comparative Assessment of Platinum Salts and Taxane Group Hypersensitivity Reactions, The Role of Skin Tests in Diagnosis? J Oncol Pharm Pract. 2021 Nov 30:10781552211050084. doi: 10.1177/10781552211050084.
• Tacar SY, Selcukbiricik F, Yilmaz M, Erturk K, Murat Sarici A, Gulturk I, Ayhan M, Tural D. Nivolumab for metastatic uveal melanoma: a multicenter, retrospective study. Melanoma Res. 2021 Oct 1;31(5):449-455. doi: 10.1097/CMR.0000000000000744.
• Özyurt E, Özçelik S, Sürmeli H, Çelik M, Ayhan M, Özçelik M. Side effects of immune-checkpoint inhibitors: Can multiple side effects be seen in a patient? J Oncol Pharm Pract. 2022 Mar;28(2):462-465. doi: 10.1177/10781552211038136.
• Dülgar Ö, Öven BB, Atcı MM, Arıkan R, Ay S, Ayhan M, Selvi O, Ozyukseler DT, Bayram E, Özcan E, Yasin Aİ, Gümüş M. Is the benefit of using adjuvant capecitabine in patients with residual triple-negative breast cancer related to pathological response to neoadjuvant chemotherapy? Expert Rev Anticancer Ther. 2022 Jul;22(7):773-780. doi: 10.1080/14737140.2022.2076670.
• Hizal M, Bilgin B, Paksoy N, Ayhan M, et all. The real-life efficacy and safety of osimertinib in pretreated advanced non-small cell lung cancer patients with T790M mutation: a Turkish Oncology Group Study. J Cancer Res Clin Oncol. 2022 Jun;148(6):1501-1508. doi: 10.1007/s00432-021-03748-7.
• Volume I, Kucukarda A, Atcı MM, Ayhan M, et all. Efficacy and safety of trastuzumab emtansine in older patients with HER2-positive advanced breast cancer: a real-world study. Tumori. 2022 Feb;108(1):19-25. doi: 10.1177/03008916211037739.
• Dogan I, Ayhan M, Gurbuz M, et all. The frequency and prognostic significance of ABO/Rh blood groups in male breast cancer patients: A multicenter study. Medicine (Baltimore). 2022 Sep 2;101(35):e30147. doi: 10.1097/MD.0000000000030147.
• Ozcelik M, Oyman A, Cil I, Duzgun O, Ozkan OF, Ayhan M. Cytoreductive Surgery versus Systemic Chemotherapy alone in Isolated Peritoneal Carcinomatosis of Colorectal Origin. J Coll Physicians Surg Pak. 2021 Nov;31(11):1308-1313. doi: 10.29271/jcpsp.2021.11.1308.
• Başoğlu T, Sakin A, Erol C, Ayhan M, et all. Real life experienceof patients with locally advanced gastric and gastroesophageal junction adenocarcinoma treated with neoadjuvant chemotherapy: a Turkish oncology group study. J Chemother. 2022 May 17:1-8. doi: 10.1080/1120009X.2022.2073159.
• Özdemir Ö, Zengel B, Yildiz Y, Ayhan M, et all. The effectiveness and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early-stage human epidermal growth factor receptor 2-positive breast cancer: Turkish Oncology Group study. Anticancer Drugs. 2022 Aug 1;33(7):663-670. doi: 10.1097/CAD.0000000000001310.
• Hizal M, Bilgin B, Paksoy N, Ayhan M, et all. The percentage of ALK-positive cells and the efficacy of first-line alectinib in advanced non-small cell lung cancer: is it a novel factor for stratification? (Turkish Oncology Group Study). J Cancer Res Clin Oncol. 2022 Sep 1. doi: 10.1007/s00432-022-04252-2.
• Hizal M, Bilgin B, Paksoy N, Ayhan M, et all. Real-world data on efficacy and safety of first-line alectinib treatment in advanced-stage, ALK-positive non-small-cell lung cancer patients: a Turkish Oncology Group study. Future Oncol. 2022 Jul;18(23):2573-2582. doi: 10.2217/fon-2022-0083.
• Topcu A, Atci MM, Secmeler S, Besiroglu M, Ayhan M, Ozkan M, Bozkurt O, Urakci Z, Ay S, Geredeli C, Yasin AI, Turk HM. Efficacy of trastuzumab and potential risk factors on survival in patients with HER2-positive metastatic gastric cancer. Future Oncol. 2021 Nov;17(31):4157-4169. doi: 10.2217/fon-2021-0398.
• Bilgin B, Sendur MAN, Yucel S, Ayhan M, et all. Real-life comparison of the afatinib and first-generation tyrosine kinase inhibitors in nonsmall cell lung cancer harboring EGFR exon 19 deletion: a Turk Oncology Group (TOG) study. J Cancer Res Clin Oncol. 2021 Jul;147(7):2145-2152. doi: 10.1007/s00432-020-03501-6.
• Atci MM, Akagunduz B, Demir M, Arikan R, Ay S, Ozer M, Ayhan M, Cil I, Demir N, Ozyurt N, Karakaya G, Cevik GT, Onder AH, Selvi O, Sakin A. The impact of adjuvant oxaliplatin and tumor sidedness on the overall survival of stage IIB colon cancer patients: a multicentre study. J Chemother. 2023 Feb;35(1):19-28. doi: 10.1080/1120009X.2022.2040770.
• Tataroglu Ozyukseler D, Ay S, Turan M, Alkan G, Ayhan M, Surmeli H, et al. The Systemic Inflammation Response Index as a Prognostic Marker in Advanced Pancreatic Cancer. EJMI 2022;6(3):367–373.
• Yıldız F, Ayhan M, Demir H, et all. Comparing the efficacy of cabazitaxel in secondline and third-Line treatment of metastatic castration-resistant prostate cancer: a multi-center experience from Turkey. International Journal of Contemporary Medical Research, 7(9), 112-116.,Doi: 10.21276/ijcmr.2020.7.9.30
• Terzioğlu K, Ayhan M. Distribution of allergens detected on patch tests of patients with allergic contact dermatitis and investigation of their atopic background. Annals of Medical Research, 29(5), 422-426., doi: 10.5455/annalsmedres.2021.07.490
• Arikan R, Atci MM, Ay S, Ayhan M, et all Prognostic significance of mucinous histology in left sided metastatic colorectal cancers with wild type RAS and evaluation of backbone chemotherapy regimens. Oncol Lett. 2023 Apr 5;25(5):208. doi: 10.3892/ol.2023.13795.
• Almuradova E, Yalcin S, Arıkan R, Ayhan M, Demir H, Cevik GT, Karaca M, Petekkaya I, Karabulut B. Survival of Patients With Metastatic Rectum Cancer Who Underwent Metastasectomy Following Conversion Chemotherapy Sans Pelvic Radiotherapy: A Turkish Oncology Group Study. Cureus 2023 May 17;15(5):e39119. doi: 10.7759/cureus.39119.
• Topcu A, Besiroglu M, Atci MM, Ayhan M, et all. Second-line Therapy after Trastuzumab Failure in HER2-Positive Metastatic Gastric Cancer: A Real-life Data. EJMI 2023;7(2):153–161. DOI: 10.14744/ejmi.2023.22720
• Book Writing:
• Drug interactions and side effects of targeted agents, Section name: (Small molecule tyrosine kinase inhibitors; ROS-1 targeted therapies (Crizotinib, Seritinib)) (2021)., AYHAN MURAT, Turkish Clinics Journal of Medical Sciences, Editor: Mehmet Aliustaoglu, Publishing number:1, Number of Pages 92, ISBN:978-625-401- 466-6, Turkish
• Approach to gastrointestinal stromal tumors and neuroendocrine tumors, Department name: (Medical approach in primary non-gastrointestinal neuroendocrine tumors) (2020)., AYHAN MURAT, Akademisyen Yayınevi, Editor: Anılır Ender, Number of editions: 1, Number of Pages 382, ISBN: 9786052585719, Turkish
• Internal medicine emergencies, Department name: (Oncological emergencies) (2022)., YILDIRIM SEDAT, AYHAN MURAT, Efe Academic Publishing, Editor: Serdar Olt, Number of editions: 1, Number of Pages 232, ISBN: 978-625-8324-66- 2, Turkish
• Physicians' chemotherapy cancer drug manual 2020, Section name: (Common chemotherapy regimens in clinical practice) (2022)., SÜMBÜL AHMET TANER, ALKAN ALI, AKSOY ASUDE, AYHAN MURAT, et all, Türkiye Klinikleri Journal of Medical Sciences, Editor: EDWAR CHU, VINCENT T. DEVITA, SAADDETIN KILIÇKAP, CEMIL BILIR, SELÇUK SEBER, Number of editions: 1, Number of pages 772, ISBN: 978-625-401-290- 7, Turkish (Book Translation)

Areas of Interests

• General Gastrointestinal Diseases
• Endoscopic procedures (gastroscopy, colonoscopy, enteroscopy, capsule endoscopy)
• Interventional endoscopy
• ERCP
• Endoscopic ultrasonography (EUS)
• Cholangioscopy
• Diseases of the biliary system and pancreas

Education:
 

• 1990 -1996 Ankara University Faculty of Medicine
• 1997 - 2001 Ankara Numune Training and Research Hospital Internal Medicine Residency
• 2001 - 2003 Turkey High Specialization Training and Research Hospital, Gastroenterology Subspecialization
• 2010 - 2010 State University of New York, USA, Department of Gastroenterology, EUS training program
   

Experience:
 

• June 2024 LIV Hospital Ulus Hospital
• 2018 - 2024 Florence Nightingale Hospitals, Gastroenterology Clinic
• 2013 - 2018 Memorial Ataşehir Hospital, Gastroenterology Clinic
• 2008 - 2013 Gaziantep University Faculty of Medicine, Department of Gastroenterology, Assoc. Prof. Dr.
• 2008 - 2008 Medicalpark Gaziantep Hospital Gastroenterology Clinic
• 2004 - 2008 Gaziantep State Hospital Gastroenterology Clinic, Endoscopy Unit Founding Physician

Publications

• Arhan M, Koklu S, Koksal AS, Yolcu OF, Koruk S, Koruk I, Kayacetin E. Alverine citrate induced acute hepatitis. World J Gastroenterol 2004; 10(15): 2303-4  ISSN: 1007-9327
• Parlak E, Cicek B, Koruk I, Disibeyaz S, Sahin B. Successful prevention of stent migration caused by placement of a second stent. Endoscopy. 2005; 37(4): 404. ISSN: 0013-726X
• Koruk I, Ozturk ZA, Köklü S, Koruk S, Ozdede S. Port-site metastasis after laparoscopic cholecystectomy. Acta Gastroenterol Belg. 2008; 71(2): 283-4      ISSN:0001-5644
• Koruk I, Parlak E, Secilmis S, Akdogan M, Koklu S.  Endoscopic sphincteroplasty with large balloon dilatation for extraction of difficult common bile duct stones. Dig Dis Sci. 2008 Jun;53(6):1737-8. ISSN: 0163-2116
• Ozkaya M, Yuzbasioglu MF, Koruk I, Cakal E, Sahin M, Cakal B. Preoperative detection of insulinomas: two case reports. Cases J. 2008 Nov 29; 1(1): 362  ISSN: 1757-1626
• Yılmaz Ö, Koruk İ, Çayır K, Koruk M, Yılmaz A. Usefullness of serum insulin-like growth factor (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) for colorectal cancer diagnosis. Int J Hematol Oncol 2009; 19(1): 23-27  ISSN: 1306-133X
• Savaş C, Koruk İ, Koruk M, Kadayıfçı A, Sarı İ. Association of prion protein with the stage of liver fibrosis in chronic viral hepatitis. Trakya Univ Tip Fak Derg. 2010; 27(4): 373-7. DOI: 10.5174/tutfd.2009.02284.1 ISSN: 1301-3149
• Buyukberber M, Koruk I, Cıkman O, Koruk M, Kucukoglu ME, Sakman A, Demir O, Sahinoz S. Serum cystatin C measurement in differential diagnosis of intra and extrahepatic cholestatic diseases. Ann Hepatol 2010; 9(1): 58-62  ISSN: 1665-2681
• Gulsen MT, Koruk I, Dogan M, Beyazit Y. Diagnostic accuracy of cascade stomach by upper gastrointestinal endoscopy in patients with obscure symptoms: A multi-center prospective trial. Clin Res Hepatol Gastroenterol. 2011; 35: 489-93. DOI: 10.1016/j.clinre.2011.03.004         ISSN: 2210-7401
• Koruk I, Aydın U, Koruk S, Aydınlı M. A newly defined biliary anatomic variation. Turk J Gastroenterol 2011; April 22(2): 232-3  DOI:10.4318/ tjg.2011.0204  ISSN: 1300-4948
• Koruk İ, Özdemir H, Aydınlı M, Tarakçıoğlu M, Koruk M. The relation between serum Cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. Turk J Gastroenterol. 2011. DOI:10.4318/tjg.2011.0256 ISSN: 1300-4948
• Aydinli M, Koruk I, Koruk S, Aydin U, Kadayifci A. Intraoperative cholangioscopy with an ultrathin endoscope for hemobilia. Endoscopy 2011;43 Suppl 2 UCTN:E410. doi: 10.1055/s-0030-1256897. Epub 2012 Jan 24
• Aydinli M, Koruk I, Dag MS, Savas MC, Kadayifci A. Ultrathin endoscopy for gastrointestinal strictures. Digestive Endoscopy 2012 May;24(3):150-3. doi: 10.1111/j.1443-1661.2011.01206.x. Epub 2011 Oct 27                 ISSN: 0915-5635
• Yılmaz Ö, Koruk İ, Onbaş O, Ozgokce M. Portal venous gas resulting from enteritis in a case with portal hypertension: Case report. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2012; 32 (4): 1195-8 ISSN: 1300-0292
• Demiryürek S, Koruk I, Bozdag Z, Ozkara E, Kaplan DS, Oztuzcu S, Cetinkaya A, Alasehirli B, Demiryürek AT. Investigation of the esophageal Rho-kinase expression in patients with Barrett's esophagus. Ultrastruct Pathol. 2013 Aug;37(4):284-9. doi: 10.3109/01913123.2013.797064        ISSN: 0191-3123
• Dag MS, Ozturk ZA, Koruk I, Kısacık B, Gerenli O, Aydınlı M, Kadayıfcı A. Intestinal Behcet's disease with severe pulmonary arterial involvement mimicking ulcerative colitis. Asian Biomedicine. 2013; 7(5): 715-8      ISSN: 1905-7415
• Dağ MS, Aydınlı M, Oztürk ZA, Türkbeyler IH, Koruk I, Savaş MC, Koruk M, Kadayıfçı A. Drug- and herb-induced liver injury: a case series from a single center. Turk J Gastroenterol. 2014 Feb;25(1):41-5. doi: 10.5152/tjg.2014.4486ISSN: 1300-4948
• Kadayifci A, Atar M, Parlar S, Balkan A, Koruk I, Koruk M. Transnasal endoscopy is preferred by transoral endoscopy experienced patients. J Gastrointestin Liver Dis. 2014 Mar;23(1):27-31     ISSN: 1841-8724
• Alasehirli B, Oğuz E, Oksuzler E, Koruk I, Oztuzcu S, Ozkara E, Karakok M, Erbagcı AB, Demiryurek AT. Investigation of intercellular adhesion molecules (ICAMs) gene expressions in patients with Barrett's esophagus. Tumour Biol. 2014 May;35(5):4907-12. doi: 10.1007/s13277-014-1644-3      ISSN: 1010-4283
• Dag M, Özturk Z, Aydınlı M, Koruk I, Kadayfçı A. Postpartum hepatotoxicity due to herbal medicine Teucrium polium. Ann Saudi Med. 2014 Nov-Dec;34(6):541-3. doi: 10.5144/0256-4947.2014.541        ISSN: 0256-4947
• Tahtacı M, İbiş M, Koruk İ, Parlak E. Endoscopic removal of fractured basket traction wire. Turk J Gastroenterol. 2014 Dec;25 Suppl 1:324-5. doi: 10.5152/tjg.2014.6582            ISSN: 1300-4948
• Dağ MS, Koruk İ, Aydınlı M, Çam H, Öztürk ZA, Kadayıfçı A. An unusual cause of esophageal ulcer; sertraline hydrochloride. Turk J Gastroenterol. 2014 Dec;25 Suppl 1:250-1. doi: 10.5152/tjg.2014.4646  ISSN: 1300-4948
• Balkan A, Yılmaz N, Balkan Y, Koruk İ, Örkmez M, Aydınlı M, Koruk M. Relationship between liver injury and serum cytokeratin 18 levels in asymptomatic hepatitis B virus carriers and in patients with chronic hepatitis B infection. Arab Journal of Gastroenterology. 2017; 18: 98–103                   ISSN: 1687-1979
• Koruk İ. How to manage difficult cannulation in ERCP. Gastroenterology and Hepatology: Open Access. 2017, 6(3): 00194. DOI: 10.15406/ghoa.2017.06.00194 ISSN: 2373-6372
• Valori R, Cortas G, de Lange T, Balfaqih OS, de Pater M, Eisendrath P, Falt P, Koruk I, et al.  Performance measures for endoscopy services: A European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.  Endoscopy 2018; 50: 1186–1204   ISSN 0013-726X
• Koruk S, Koruk I, Mizrak A. A, Bilgi M, Gul R, Bozgeyik S. Dexmedetomidine or midazolam in combination with propofol for sedation in endoscopic retrograde cholangiopancreatography: a randomized double blind prospective study. Videosurgery Miniinv. 2020; 15(3): 526-32 doi.org/10.5114/wiitm.2020.95066

Dr. Binnur Simsek is a gastroenterology specialist. She has experience in liver cirrhosis, portal hypertension, hepatocellular carcinoma, liver transplantation, and viral hepatitis (B, C, Delta). She also treats alcoholic and non-alcoholic fatty liver disease, peptic ulcers, gastrointestinal bleeding, and inflammatory bowel diseases such as ulcerative colitis and Crohn’s colitis.

She completed her medical and gastroenterology training at Istanbul University Faculty of Medicine. Dr. Simsek has worked at Istanbul University, Sanlıurfa Education and Research Hospital, Liv Hospital, and Istinye University. She is a member of the Turkish Association for the Study of the Liver and the Turkish Society of Gastroenterology.

Dokter lulus dari Fakultas Kedokteran Universitas Uludağ dengan Diploma Kedokteran pada tahun 1983 dan menyelesaikan residensi dalam Onkologi Radiasi di Pusat Onkologi & Kedokteran Nuklir di Istanbul pada tahun 1990. Beasiswa pascadoktoral dalam Termoradioterapi diselesaikan di Universitas Thomas Jefferson dari tahun 1990 hingga 1994. Dokter menjabat sebagai Profesor dan Ketua Departemen Onkologi Radiasi di Fakultas Kedokteran Universitas Uludağ dari tahun 1994 hingga 2005 dan menjadi Koordinator Akreditasi Fakultas dari tahun 2001 hingga 2004.<\/p>

Dari tahun 2004 hingga 2017, dokter menjadi Profesor dan Direktur Departemen Onkologi Radiasi di Pusat Medis Anadolu, juga menjabat sebagai Koordinator Ilmu Onkologi dari tahun 2011 hingga 2017. Saat ini, dokter adalah Direktur Ilmu Onkologi di Rumah Sakit Medicana Bursa, posisi yang dipegang sejak tahun 2018.<\/p>