Sheba Pediatric CAR-T Program for Primary CNS Lymphoma
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Prosedur Medis
- Konsultasi dengan ahli hematologi
- Diagnosis komprehensif limfoma
- Analisis darah lanjutan
- Tes darah limfoma
- PET/CT pada limfoma
- Biopsi nodus limfa sentinel
- Diagnosis onkologi kompleks
- Konsultasi dengan onkohematolog
- Terapi sel T CAR
- Tes Anti-HIV
- Tes Anti-HBC
- Uji Anti-HCVAb
- Tes darah
- Tes darah biokimia
- Biopsi
- Rontgen dada
- Hitung darah lengkap (CBC)
- Konsultasi dengan ahli onkologi
- Konsultasi dengan ahli hematologi
- Konsultasi dengan ahli imunologi
- Konsultasi dengan dokter hematologi pediatrik
- Konsultasi dengan dokter anak
- Hitung darah lengkap dengan penanda kanker dan proteinogram
- Elektrokardiogram (EKG)
- Ekokardiografi
- Konsultasi dengan ahli jantung
- MRI Kepala
- PET/CT
- Konsultasi dengan onkohematologis
- layanan perawat 24 jam
- 3 kali makan per hari oleh ahli gizi
Durasi
- 21 hari di rumah sakit
Akomodasi
Rawat Inap
Transportasi
Transfer bandara-klinik-bandara
Informasi tambahan
Sheba Pediatric CAR-T Program for Primary CNS Lymphoma
At Sheba Medical Center, children and young patients with primary central nervous system (CNS) lymphoma have access to one of the most advanced and specialized CAR-T therapy programs in the world. This rare and complex lymphoma, affecting the brain and spinal cord, requires highly precise and coordinated care, especially in relapsed or treatment-resistant cases.
A Personalized Treatment Designed for Each Patient
CAR-T therapy uses the patient’s own immune system to recognize and destroy cancer cells. For CNS lymphoma, this innovative approach offers a targeted option when conventional therapies are no longer sufficient.
At Sheba, the entire CAR-T process is performed on-site, ensuring speed, precision, and optimal cell quality:
Apheresis – collection of the patient’s T-cells
Cell Engineering – genetic modification at Sheba’s Advanced Biotherapy Center
Infusion – reintroduction of modified cells to target lymphoma cells
Because no steps are outsourced, treatment can begin quickly and is typically completed within ~10 days. CAR-T acts as a “living therapy,” continuing to work in the body and offering the potential for long-term disease control.
Expert Pediatric Leadership and Multidisciplinary Care
The program is led by Prof. Amos Toren, a globally recognized expert in pediatric hemato-oncology and cellular therapies, with decades of experience and over 1,500 bone marrow transplants performed.
Given the complexity of CNS lymphoma, care is delivered through a multidisciplinary team, including pediatric hemato-oncologists, neurologists, neurosurgeons, and radiology experts.
The program includes:
Specialized pediatric CAR-T units with 24/7 monitoring
Advanced neuro-imaging and precision diagnostics
A supportive, family-centered environment
Full international patient services, including travel and care coordination
Proven Expertise in Complex and High-Risk Cases
Sheba is a global leader in CAR-T therapy, with strong outcomes across hematologic cancers:
~90% remission in pediatric patients
~80% in young adults (up to 23 years)
~70% in adults
The team has extensive experience in treating rare and high-risk conditions, including CNS involvement, offering advanced options when other treatments are limited.
Comprehensive Evaluation and Ongoing Support
Each patient undergoes a full diagnostic work-up, including:
advanced brain and spinal imaging (MRI/CT), bone marrow evaluation, genetic and molecular testing, and cardiac and pulmonary assessment.
Care is provided in English, Russian, and Arabic, ensuring families feel supported and informed throughout the entire journey.
A Trusted Place for Advanced Pediatric Neuro-Oncology Care
By combining cutting-edge immunotherapy, neurological expertise, and compassionate care, Sheba provides one of the most advanced environments for treating primary CNS lymphoma with CAR-T—focused on achieving the best possible outcomes and quality of life for every patient.
Bantuan Bookimed 24/7
- Koordinator medis pribadi
- Pengaturan perjalanan medis — pemesanan tiket pesawat dan kamar hotel dengan harga mitra khusus
- Pendampingan pasien selama perjalanan medis
Harga program
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Dokter
Prof. Amos Toren, MD, PhD, MHA, is a pediatric hemato-oncologist and BMT specialist. He served as Director of Pediatric Hemato-Oncology and BMT at Sheba Medical Center.
He is board certified in Pediatrics, Pediatric Hemato-Oncology, and Bone Marrow Transplantation. He holds a PhD in Human Genetics. He was Head of the Hematology Division at Tel Aviv University for two terms. He is a member of ASH, COG, ESPHI, EBMT, and CIBMTR. He also serves on the Ministry of Health Cord Blood Committee.
He led one of Israel’s most advanced pediatric oncology and BMT programs. The program treated children and young adults. His focus includes leukemia and lymphoma, immunodeficiencies, and rare cancers. He specializes in BMT and CAR T-cell therapy.
His translational research covers CAR T cells, cytokine-induced killer cells, pediatric brain tumors, and targeted therapies. He has worked with St. Anna, the NIH, and St. Jude. His publications include studies on pediatric SCT prophylaxis and PARP resistance.
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Tentang klinik
Sheba Medical Center adalah salah satu rumah sakit terbaik di Israel dan di dunia. Majalah Newsweek International menempatkan Rumah Sakit Sheba di 10 besar rumah sakit dunia pada tahun 2020. Rumah sakit ini memiliki 1.990 spesialisasi dan lebih dari 1.500.000 pasien dari seluruh dunia mengunjungi Rumah Sakit Sheba untuk pengobatan setiap tahun.
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